| International
Cancer Vaccine Symposium
In London 2004
“Clinical
and Laboratory Advances in Cancer Vaccines and Immunotherapies”
Friday-Sunday 12-14 November
2004
Royal Society of Medicine, London, the United Kingdom
FRIDAY 12 NOVEMBER 2004
18:30 Speakers' Reception and Buffet at RSM
SATURDAY 13 NOVEMBER 2004
8:30 Coffee and Registration
9:10 Welcome Address
Sir John Lilleyman, President,
RSM
Dr. Kenichiro Hasumi, Chairman, HIRF
SESSION 1: KEYNOTE SPEAKERS
Chair: Dr Lowell Harmison, PHS (RET.), USA
9:30 Cancer: a Global Disease
Dr. Yank D. Coble, President,
the World Medical Association
10:00 A UK Perspective
Prof. Karol Sikora, Imperial
College School of Medicine
SESSION 2: TARGETING VIRAL
ANTIGENS
Chair: Prof. Angus Dalgleish, St George’s Hospital
Medical School
11:00 HPV Virus-like Particles and Vaccine Development
Dr. Douglas Lowy, National
Cancer Institute/NIH, USA
11:30 Therapeutic HPV vaccines
Prof. Peter Stern, Paterson
Institute, Manchester
12:00 Vaccines Targeting EB Positive Malignancies
Prof. Alan Rickinson, The University
of Birmingham
SESSION 3: APPROACHES TO IMMUNOTHERAPY
AND CLINICAL TRIALS
Chair: Prof. Robert Hawkins, University of Manchester
13:30 Critical Issues in the Development of
Cancer Vaccines
Dr. Jeffrey Schlom, National
Cancer Institute/NIH, USA
14:00 Overcoming the tumour Challenge to Cancer
Vaccines by Focusing on Premalignant Disease
Dr. Olivera Finn, University
of Pittsburgh, USA
14:30 DNA Vaccines
Dr. Christian Ottensmeier,
University of Southampton
15:00 Immunostimulatory Antibodies
Prof. Martin Glennie, University
of Southampton
15:30 The Role of Allogeneic Cells and Dendritic
Cell Antigen Presentation in the Development of Effective
Cancer Vaccines
Prof. Angus Dalgleish, St George's
Hospital Medical School
SESSION 4: REGULATORY ISSUES
IN CLINICAL TRIALS
Chair: Dr. Lowell Harmison, PHS (RET.), USA
16:30 The US Perspective
Dr. Lowell Harmison, Dr. Douglas
Lowy, Dr. Jeffrey Schlom, Dr. Jeffrey Weber
16:50 The UK Perspective
Dr. Brian Davies, Clinical
Trials Consultant, MHRA
17:10 The French Perspective
Dr. Jean-Ybes Bonnefoy, Director
Cancerople Lyon Rhone-Alpes, France
17:30 The Russian Perspective
Prof. Andrei Kozlov, St. Petersburg
University, Russia
17:30 The Russian Perspective
Prof. Andrei Kozlov, St. Petersburg
University, Russia
Panel Discussion
All Session 4 Speakers plus Professor
Schuler and Professor Stingl
18:00 Close of Day One
18:30 Dinner for All Attendees at RSM
SUNDAY 14 NOVEMBER 2004
SESSION 5: DENDRITIC CELLS
Chair: Dr. Kayo Inaba, Kyoto University, Japan
9:15 Dendritic Cells as Targets for Immunotherapy
Dr. Ralph Steinman, Rockefeller
University, USA
9:45 Dendritic Cell-Based Vaccination Against
Cancer
Prof. Gerold Schuler, University
of Erlagen, Germany
10:15 Dendritic Cell Vaccine in Melanoma
Dr. Jacques Banchereau, Baylor
Institute for Immunology Research, USA
11:15 Experimental Strategies to Enhance the
Potency of Dendritic Cell-Based Cancer Vaccines for
Clinical Use
Dr. James Mule, Moffitt Cancer
Centre, USA
11:45 Arming dendritic cells for Cancer Immunotherapy
Prof. Laurence Young, The University
of Birmingham
12:15 Immunostimulation via the Skin - a Means
of Cancer Immunotherapy
Prof. Georg Stingl, University
of Vienna Medical School, Austria
SESSION 6: IMMUNOTHERAPEUTIC
TARGETS
Chair: Prof. Tim Elliott, University of Southampton
13:45 Exploiting the Intentional Induction of
Autoimmune Reactivity to Treat Metastatic Disease
Dr. Richard Vile, Mayo Clinic,
USA
14:15 Clinical Evaluation of 5T4 as a Novel
Target for Cancer Immunotherapy
Prof. Robert Hawkins, University
of Manchester
14:45 Immunodominance: “Lessons from Clinical
Traials in Melanoma Patients”
Prof. Vincenzo Cerundolo, University
of Oxford
SESSION 7: IMMUNE RESPONSES
Chair: Prof. Peter Johnson, University of Southampton
15:45 Infusion of Anti-CD3/Anti-CD28 Expanded
T-cells Post-Stem Cell Treatment Alters an Immune Response
to a Pre-Transplant Vaccine: Investigation of the Possible
Role of Cytokines/Chemokines in this Response
Dr. Dean Mann, University of
Maryland, USA
15:15 Precision Guiding of Cytolytic T-lymphocyte
Responses
Dr. Cornelis Melief, University
Hospital Leiden, the Netherlands
16:45 New Paradigms in Antigen Specific Approaches
to Melanoma
Dr. Jeffrey Weber, Norris Comprehensive
Cancer Center, University of Southern
California, USA
SESSION 8: SUMMARY
Chair: Prof. Robin Williamson, Dean, RSM
17:15 Summary Talk
Prof. Hans Wigzell, Karolinska
Institutet, Sweden
CLOSING
17:45 Closing Words
18:00 Close of Symposium
19:00 Speakers’ Dinner
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